Study on the changes of IL-3 and its receptor in mice with immune-mediated aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 684-686, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-347885
ABSTRACT
The aim of this study was to find new idea for clinical treatment of aplastic anemia. Immune-mediated aplastic anemia mice were developed, IL-3 in the supernatant with PHA stimulating splenic cells was detected by ELISA, semi-quantiting analysis of IL-3R was performed by point hybridization. The results showed that the IL-3 level in the supernatant with PHA stimulating splenic cells of immune-mediated aplastic anemia mice was higher than controls, difference between them was significant (P <0.001), while amount of IL-3 receptor by semi-quantiting analysis was lower than control significantly. In conclusion, the IL-3 receptor expression level is important for pathogenesis and treatment strategy of aplastic anemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Medula Óssea
/
RNA Mensageiro
/
Receptores de Interleucina-3
/
Interleucina-3
/
Alergia e Imunologia
/
Genética
/
Anemia Aplástica
/
Camundongos Endogâmicos BALB C
/
Camundongos Endogâmicos DBA
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2004
Tipo de documento:
Artigo
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