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Study on the changes of IL-3 and its receptor in mice with immune-mediated aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 684-686, 2004.
Artigo em Chinês | WPRIM | ID: wpr-347885
ABSTRACT
The aim of this study was to find new idea for clinical treatment of aplastic anemia. Immune-mediated aplastic anemia mice were developed, IL-3 in the supernatant with PHA stimulating splenic cells was detected by ELISA, semi-quantiting analysis of IL-3R was performed by point hybridization. The results showed that the IL-3 level in the supernatant with PHA stimulating splenic cells of immune-mediated aplastic anemia mice was higher than controls, difference between them was significant (P <0.001), while amount of IL-3 receptor by semi-quantiting analysis was lower than control significantly. In conclusion, the IL-3 receptor expression level is important for pathogenesis and treatment strategy of aplastic anemia.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Medula Óssea / RNA Mensageiro / Receptores de Interleucina-3 / Interleucina-3 / Alergia e Imunologia / Genética / Anemia Aplástica / Camundongos Endogâmicos BALB C / Camundongos Endogâmicos DBA Limite: Animais Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Medula Óssea / RNA Mensageiro / Receptores de Interleucina-3 / Interleucina-3 / Alergia e Imunologia / Genética / Anemia Aplástica / Camundongos Endogâmicos BALB C / Camundongos Endogâmicos DBA Limite: Animais Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2004 Tipo de documento: Artigo