Laboratory study on near-tetraploid acute myelogenous leukemia of childhood / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 263-266, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-347941
ABSTRACT
Near-tetraploidy is a rare cytogenetic abnormality in myelocytic malignancies in children, and its significance is unknown. To investigate the characteristics of near-tetraploidy in a child with acute myelogenous leukemia (AML-M4), bone marrow smears were prepared for morphological analysis. Bone marrow samples were collected for flow cytometry, and prepared by short-term (24 hrs) unstimulated culture and R-banding for conventional cytogenetic assay. In this case, the morphological analysis of bone marrow cells showed large and prominent nuclei. The chromosomal analysis (R-banding) demonstrated a near-tetraploidy. Combined with morphological and immunophenotypic results, AML-M4 was confirmed. The patient was given four cycles of chemotherapy, and finally achieved clinical remission. However, the duration achieving the remission in the child was longer than AML children with normal karyotype. It is believed that near-tetraploid karyotype may have a great significance to the therapy and prognosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Poliploidia
/
DNA de Neoplasias
/
Células da Medula Óssea
/
Leucemia Mieloide Aguda
/
Imunofenotipagem
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Genética
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2009
Tipo de documento:
Artigo
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