Neurobehavioral function of neonatal mice following excitotoxic brain damage / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 191-193, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-347966
ABSTRACT
<p><b>OBJECTIVE</b>To assess the changes of neurobehavioral function in a neonatal mouse model of excitotoxic brain damage.</p><p><b>METHODS</b>Fifty-five 5-day-old ICR neonatal mice were randomly assigned to three groups blank (no intravenous) control (n=20), saline control (n=20) and excitotoxic brain damage model (ibotenic acid treatment, n=15). Behavioral function was evaluated by the surface righting reflex test (postnatal days 6-10), the swimming test (postnatal days 8-12) and the Y-maze discrimination learning test (postnatal days 33-34).</p><p><b>RESULTS</b>Righting time in the surface righting reflex test in the ibotenic acid treatment group on postnatal days 6-10 was more prolonged than that in the two control groups (p<0.05). Swimming test scores in the ibotenic acid treatment group were significantly lower than those in the two control groups (p<0.05). In the Y-maze discrimination learning test, the mice from the ibotenic acid treatment group performed significantly worse than two control groups, presenting with increased learning times (19.79+/-2.42 vs 16.29+/-2.48 or 16.30+/-2.37; p<0.05) and achieving a lower correct percentage (86.7% vs 96.5% or 95.0%) (p<0.05).</p><p><b>CONCLUSIONS</b>The developmental reflexes and learning and memory functions were impaired in neonatal mice following excitotoxic brain damage. Behavioral testing is useful in the evaluation of early developmental reflexes and long-term neurobehavioral outcome in neonatal mice with excitotoxic brain damage.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Natação
/
Comportamento Animal
/
Encéfalo
/
Aprendizagem em Labirinto
/
Agonistas de Aminoácidos Excitatórios
/
Toxicidade
/
Ácido Ibotênico
/
Animais Recém-Nascidos
/
Camundongos Endogâmicos ICR
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2009
Tipo de documento:
Artigo
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