Effect of oral carcinoma-associated fibroblasts on extracellular signal-regulated kinases pathway in the lingual carcinoma cell line / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 490-492, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-348011
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of oral carcinoma-associated fibroblasts (CAFs) on extracellular signal-regulated kinases (ERK) pathway in a lingual carcinoma cell line.</p><p><b>METHODS</b>The lingual carcinoma cell line, Tca8113 was stimulated by conditioned medium from oral CAFs, or cocultured with oral CAFs for definite time. Total ERK and pERK in Tca8113 lysate were detected by Western blotting, and the ratio between pERK and ERK were calculated.</p><p><b>RESULTS</b>Both stimulation by conditioned medium and coculture induced prompt phosphorylation of ERK, and increased the ratio between pERK and ERK.</p><p><b>CONCLUSION</b>Oral CAFs can activate ERK pathway of carcinoma cells.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Neoplasias Bucais
/
Neoplasias da Língua
/
Linhagem Celular
/
Técnicas de Cocultura
/
Linhagem Celular Tumoral
/
MAP Quinases Reguladas por Sinal Extracelular
/
Fibroblastos
Limite:
Humanos
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2007
Tipo de documento:
Artigo
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