Expression and significance of B7-H1 and its receptor PD-1 in human gastric carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 192-195, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-348135
ABSTRACT
<p><b>OBJECTIVE</b>The B7-H1/PD-1 co-signaling pathway has recently been found to play a pivotal role in the immune evasion of tumor cells from host immune system. The aim of this study was to examine the B7-H1 and PD-1 expression and TILs status in gastric cancer and to elucidate the clinical relevance of B7-H1 and PD-1 to the pathogenesis of gastric carcinoma.</p><p><b>METHODS</b>Immunohistochemistry and ANAE histochemical staining were used to investigate the in situ expression of B7-H1 and PD-1 and TILs status in the gastric tissues. RT-PCR was used to explore B7-H1 and PD-1 expression at the transcriptional level. The B7-H1 expression at protein level was detected by Western blot.</p><p><b>RESULTS</b>Expression of B7-H1 and PD-1 was found to be increased in gastric carcinoma, but absent in normal gastric tissue. B7-H1 expression in gastric carcinoma was inversely correlated with TILs infiltration. B7-H1 but not PD-1 expression in tumor tissue was significantly correlated with some clinicopathhological variables including depth of invasion, lymph node metastasis and distant metastasis.</p><p><b>CONCLUSION</b>B7-H1 and PD-1 expressions are increased in gastric carcinoma. This signaling pathway may inhibit antitumor immune responses in gastric carcinoma. B7-H1 expression plays a critical role in the pathogenesis of human gastric carcinoma,and might be a promising prognostic marker and therapeutic target in the treatment of this disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias Gástricas
/
RNA Mensageiro
/
Linfócitos T CD4-Positivos
/
Antígenos CD
/
Subpopulações de Linfócitos
/
Linfócitos do Interstício Tumoral
/
Alergia e Imunologia
/
Proteínas Reguladoras de Apoptose
/
Antígeno B7-H1
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2008
Tipo de documento:
Artigo
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