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Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 913-916, 2007.
Artigo em Chinês | WPRIM | ID: wpr-348174
ABSTRACT
<p><b>OBJECTIVE</b>To assess the polymorphism of UGT1A gene in Chinese, and to investigate the correlation between UGT1A polymorphism and irinotecan toxicity in colorectal cancer patients.</p><p><b>METHODS</b>70 patients with advanced colorectal cancer were treated with irinotecan and 5-fluorouracil. Polymorphism analysis was performed in all those patients and 100 healthy subjects. Genomic DNA was extracted from peripheral blood and genotyped using polymerase chain reaction and direct sequencing.</p><p><b>RESULTS</b>14 patients exhibiting grade 3 - 4 neutropenia (20.0%), 16 patients experienced grade 2 - 4 diarrhea (22.9%), including only 4 patients with grade 3 - 4 diarrhea (5.7%). Compared with TA6/7 and TA7/7, UGT1 A1 * 28 wild genotype TA6/6 was significantly associated with reduced toxicity (42.1% vs. 15.7%, P = 0.027). There was no significant difference in the distribution of UGT1A genotypes between colorectal cancer patients and healthy subjects.</p><p><b>CONCLUSION</b>Chinese patients exhibit less irinotecan-related diarrhea due to higher frequence of UGT1A A1 * 28 wild genotype TA6/6.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Camptotecina / Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Estudos de Casos e Controles / China / Glucuronosiltransferase / Predisposição Genética para Doença / Usos Terapêuticos / Povo Asiático Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Humanos País/Região como assunto: Ásia Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Camptotecina / Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Estudos de Casos e Controles / China / Glucuronosiltransferase / Predisposição Genética para Doença / Usos Terapêuticos / Povo Asiático Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Humanos País/Região como assunto: Ásia Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2007 Tipo de documento: Artigo