Effects of integrin on differentiation of mesenchymal stem cells / 生理学报
Acta Physiologica Sinica
;
(6): 498-508, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-348247
ABSTRACT
Integrin is a family of transmembrane heterodimer receptor formed by α and β two subunits, which transduces external signals into cells through reaction with extracellular matrix and is crucial to cell survival, migration, and differentiation. With the deep studies on multipotential differentiation of mesenchymal stem cells (MSCs), researchers found that the differentiation of MSCs depends on integrin related signaling pathways, including MAPK, Wnt and PI3K signaling pathways and so on. However, there are many factors affecting the expression and activation of integrin, such as nano morphology microenvironment, ascorbic acid, bone morphogenetic protein-2, fibronectin, cadherin, fluid shear stress and so on. In this review, we mainly discuss the integrin expression, the promoting effects of integrin on the differentiation of MSCs and their underlying mechanisms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS