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Involvement of aquaporin-4 in synaptic plasticity, learning and memory / 生理学报
Acta Physiologica Sinica ; (6): 335-343, 2017.
Artigo em Chinês | WPRIM | ID: wpr-348266
ABSTRACT
Aquaporin-4 (AQP-4) is the predominant water channel in the central nervous system (CNS) and primarily expressed in astrocytes. Astrocytes have been generally believed to play important roles in regulating synaptic plasticity and information processing. However, the role of AQP-4 in regulating synaptic plasticity, learning and memory, cognitive function is only beginning to be investigated. It is well known that synaptic plasticity is the prime candidate for mediating of learning and memory. Long term potentiation (LTP) and long term depression (LTD) are two forms of synaptic plasticity, and they share some but not all the properties and mechanisms. Hippocampus is a part of limbic system that is particularly important in regulation of learning and memory. This article is to review some research progresses of the function of AQP-4 in synaptic plasticity, learning and memory, and propose the possible role of AQP-4 as a new target in the treatment of cognitive dysfunction.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Potenciação de Longa Duração / Depressão Sináptica de Longo Prazo / Aquaporina 4 / Hipocampo / Aprendizagem / Memória / Plasticidade Neuronal Limite: Animais / Humanos Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Potenciação de Longa Duração / Depressão Sináptica de Longo Prazo / Aquaporina 4 / Hipocampo / Aprendizagem / Memória / Plasticidade Neuronal Limite: Animais / Humanos Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2017 Tipo de documento: Artigo