Effects of growth differentiation factor-15 (GDF-15) on neurological systems, cardiovascular diseases, and cancer progression / 生理学报
Acta Physiologica Sinica
;
(6): 109-121, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-348293
ABSTRACT
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. It has been suggested that GDF-15 has neurotropic effects in the nervous system. Our studies showed that GDF-15 modulated the expression of neuronal Kand Caion channels and increased the release of excitatory transmitter in the medial prefrontal cortex of mice. GDF-15 is also involved in the complex modulation of cancer and cardiovascular disease. Here, we reviewed studies involving the modulation of GDF-15 expression and its mechanisms, the primary pathological and physiological functions of GDF-15 in neurological and cardiovascular systems, and its role in cancer progression. The biological effects and the values of GDF-15 in basic research and clinical applications were also addressed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Lesões Encefálicas
/
Canais de Cálcio
/
Doenças Cardiovasculares
/
Canais de Potássio
/
Regulação para Cima
/
Fator de Crescimento Transformador beta
/
Córtex Pré-Frontal
/
Progressão da Doença
/
Fator 15 de Diferenciação de Crescimento
/
Inflamação
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2017
Tipo de documento:
Artigo
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