Study on effects of acupuncture at the heart meridian on gene expression pattern of heart in rats with acute myocardial ischemia / 中国针灸
Chinese Acupuncture & Moxibustion
; (12): 587-594, 2006.
Article
em Zh
| WPRIM
| ID: wpr-348493
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To reveal the mechanism of acupuncture at the Heart meridian in treatment of myocardial ischemia from gene level.</p><p><b>METHODS</b>A model of acute myocardial ischemia was made by ligation of left anterior descending branch of the coronary artery. Changes of gene expression pattern of the Lung meridian group, the Heart meridian group and the model group in the heart were compared.</p><p><b>RESULTS</b>Differential expression genes and expression sequence tags (ESTs) were 14 with signal log ratio > or = 1 and 20 with signal log ratio < or = -1, mainly included immunological and inflammatory reaction relative genes, cell signal transduction and transferrin relative genes, and others, in the Lung meridian group vs the model group. Differential expression genes and ESTs were 20 with signal log ratio > or = 1 and 70 with signal log ratio < or = -1, mainly included ion channel and transport protein relative genes, cell apoptosis and stress reaction protein relative genes, metabolism relative genes, cell signal transduction and transferrin relative genes, DNA's binding, transcription and transcriptional factor relative genes, immunological and inflammatory reaction relative genes, and others, in the Heart meridian group vs the model group.</p><p><b>CONCLUSION</b>In number and types of differential expression genes and ESTs with signal log ratio > or = 1 or < or = -1, the changes in the Heart meridian group vs the model group were obviously different from those in the Lung meridian group vs the model group, indicating that the Heart meridian has relative specificity in protecting against acute myocardial ischemia.</p>
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Índice:
WPRIM
Assunto principal:
Terapêutica
/
Terapia por Acupuntura
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Eletroacupuntura
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Meridianos
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Ratos Sprague-Dawley
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Isquemia Miocárdica
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Coração
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Acupuncture & Moxibustion
Ano de publicação:
2006
Tipo de documento:
Article