Genetic subtype and epidemiological feature of HIV-1 circulating strains among recently infected patients in Fujian province / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 714-719, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-348587
ABSTRACT
<p><b>OBJECTIVE</b>In order to evaluate the distribution of genetic subtypes and epidemiological feature of HIV-1 circulating strains in Fujian province.</p><p><b>METHODS</b>Blood samples and epidemiological data were collected from 104 newly infected patients who were distinguished by BED-CEIA methodology, during 2011-2012. Viral sequences(n = 81) of HIV-1 gag, env, and pol segments were amplified by nested PCR.</p><p><b>RESULTS</b>Subtypes B and four Circulating Recombinant Forms, (CRF01_AE, CRF07_BC, CRF08_BC and CRF55_01B) were found in the samples, CRF01_AE(45.68%)and CRF07_BC(35.80%) were the two main HIV-1 strains in Fujian province. Compared with previous data, the proportion of CRF07_BC rose significantly while it gradually decreased in CRF01_AE. Heterosexual contact was still the principal transmission route in Fujian province, but the number of infection among men-who-have-sex-with- men grew rapidly.</p><p><b>CONCLUSION</b>Results from this study suggested that different subtypes of HIV-1 strain existed in Fujian province. The distribution of subtypes and the mode of transmission were changing with the progress of epidemic. Dynamic monitoring of the molecular epidemiology trends of HIV-1 infection should be enhanced.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Infecções por HIV
/
China
/
Epidemiologia
/
HIV-1
/
Classificação
/
Epidemiologia Molecular
/
Genética
/
Genótipo
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2014
Tipo de documento:
Artigo
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