Dynamic expression of antigen MG7 in the gastric cancer and gastric precancerous lesions / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 494-497, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-348826
ABSTRACT
<p><b>OBJECTIVE</b>To study the kinetics of MG7 expression in the process of gastric cancer development.</p><p><b>METHODS</b>The expression level of antigen MG7 on gastric mucosa in 406 cases was determined by immunohistochemical techniques. The classification of intestinal metaplasia of gastric mucosa was determined by histochemistry techniques on gastric mucosa in 82 cases.</p><p><b>RESULTS</b>The positive rates of MG7 expression in normal gastric mucosa, intestinal metaplasia and dysplasia of gastric mucosa and gastric cancer all increased gradually (P < 0.01). The positive rates of MG7 expression in superficial gastritis, atrophic gastritis and gastric cancer increased in sequence (P < 0.01). The positive rate of antigen MG7 expression in III intestinal metaplasia of gastric mucosa was significantly different with I and II intestinal metaplasia (P < 0.05).</p><p><b>CONCLUSIONS</b>MG7 was quite specific in gastric cancer thus could be used as a good index in the screening of gastric cancer. Patients with III intestinal metaplasia of gastric mucosa, atrophic gastritis and dysplasia of gastric mucosa should be closely followed in order to improve the early detection on gastric cancer. It seemed that MG7 was clinically valuable in the dynamic follow-up of gastric precursors.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Lesões Pré-Cancerosas
/
Neoplasias Gástricas
/
Imuno-Histoquímica
/
Química
/
Diagnóstico
/
Alergia e Imunologia
/
Mucosa Gástrica
/
Metaplasia
/
Antígenos de Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2003
Tipo de documento:
Artigo
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