A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberculosis / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 389-392, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-348860
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis.</p><p><b>METHODS</b>Case-control study was conducted. PCR-RFLP technique was used to detect the C/T polymorphism in VDR gene. Information on related factors of tuberculosis was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.</p><p><b>RESULTS</b>A sample of 76 cases and 171 controls was studied. The genotype frequencies of VDR-FF, VDR-Ff and VDR-ff were 38.2%, 44.7%, 17.1% and 52.6%, 40.9%, 6.4% respectively. VDR-ff was significantly overrepresented in case group, the OR (95% CI) was 3.668 (1.483 - 9.071) when comparing with FF genotype. The significant association remained after adjusting BCG immunization and smoking, the OR (95% CI) was 3.036 (1.117 - 8.253).</p><p><b>CONCLUSION</b>The VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tuberculose Pulmonar
/
Polimorfismo de Fragmento de Restrição
/
Estudos de Casos e Controles
/
Modelos Logísticos
/
Reação em Cadeia da Polimerase
/
Receptores de Calcitriol
/
Predisposição Genética para Doença
/
Genética
/
Genótipo
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Criança
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2003
Tipo de documento:
Artigo
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