Advances in parallel artificial membrane permeability assay and its applications / 药学学报
Acta Pharmaceutica Sinica
;
(12): 890-895, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-348887
ABSTRACT
With the development of drug discovery, more and more candidate compounds need to be studied. Methods that can screen compound rapidly received significant attention. Parallel artificial membrane permeability assay (PAMPA) as a powerful tool has been applied to drug studies. It uses an artificial lipid membrane to mimic the barrier for drug permeability studies. This article introduces the establishment and characteristics of PAMPA, as well as its applications in screening compounds. It can be used as models (e.g. predicting the ability of compound in gastro-intestinal absorption, blood-brain barrier transportation and skin penetration) by changing the component of artificial lipid membrane. PAMPA has advantages in high throughput selection of valuable compound with low cost, versatile, low dose, and good reproducibility.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Permeabilidade
/
Absorção Cutânea
/
Estômago
/
Preparações Farmacêuticas
/
Barreira Hematoencefálica
/
Permeabilidade da Membrana Celular
/
Absorção
/
Absorção Intestinal
/
Membranas Artificiais
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo
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