Chemical proteomics and discovery of drug targets / 药学学报
Acta Pharmaceutica Sinica
;
(12): 877-882, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-348889
ABSTRACT
Medical community and pharmaceutical companies are currently facing a dire need for discovery and identification of new druggable targets. However, the discovery of small-molecule target is an important and arduous task for the biological and medical scientists. To overcome the bottlenecks for target validation, many new approaches are being developed, such as chemical proteomics. As a part of proteomics approaches, chemical proteomics employs small-molecule compounds that can specifically interact with the target protein to interfere with and detect proteomics. Therefore, new target identification, drug discovery and research on multi-target-directed drugs will all be benefited from the further advances in chemical proteomics approaches. Chemical proteomics has the potential to greatly enhance the efficiency of the drug discovery process.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medicamentos de Ervas Chinesas
/
Desenho de Fármacos
/
Química
/
Sistemas de Liberação de Medicamentos
/
Análise Serial de Proteínas
/
Proteômica
/
Bibliotecas de Moléculas Pequenas
/
Descoberta de Drogas
/
Métodos
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo
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