Synthesis and antiviral activities of geldanamycin analog TC-GM in vitro / 药学学报
Acta Pharmaceutica Sinica
;
(12): 683-687, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-348900
ABSTRACT
In order to find antiviral compounds with novel structures, geldanamycin and lamivudine with different antiviral mechanisms were conjunctively synthesized to acquire a new compound TC-GM, and the antiviral activity of TC-GM was measured. The antiviral activity against HIV-1 was examined by p24 antigen ELISA kit. The activity against HBV was examined by dotblot. The activity against HSV and CoxB virus was examined by CPE. TC-GM exhibited broad-spectrum antiviral activities similarly like geldanamycin. TC-GM inhibited the replication of different viruses, including HIV-1, HBV, HSV 1 and 2, CoxB6. TC-GM showed more potent inhibitory activity against HIV-1 and HBV than other detected virus.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Patologia
/
Farmacologia
/
Fisiologia
/
Virologia
/
Replicação Viral
/
Células Vero
/
Chlorocebus aethiops
/
Química
/
Vírus da Hepatite B
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo
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