Association of rs2298212 polymorphism in OX40 gene with coronary atherosclerotic disease in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 171-175, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-349018
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of the OX40 gene rs2298212G/A polymorphism with coronary atherosclerotic disease (CAD) in Chinese Han population.</p><p><b>METHODS</b>Five hundred and thirty six CAD patients and 544 age and ethnic matched controls of Chinese Han population were recruited from Qilu Hospital, Shandong University. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype the selected single nucleotide polymorphism. Distributions of genotypic and allelic frequencies were analyzed by Chi-square test.</p><p><b>RESULTS</b>The distribution of genotypic and allelic frequencies have no significant differences between the CAD cases and controls(P> 0.05), even after adjusting for age, gender, body mass index, systolic blood pressure, diastolic blood pressure, glucose, total cholesterol, and triglyceride. However, when substratification analysis of the involved coronary artery vessels was performed, significant difference was found between single-vessel and triple-vessel (P= 0.02, OR = 1.56, 95% CI 1.08-2.26) involvement.</p><p><b>CONCLUSION</b>The rs2298212G/A polymorphism in OX40 gene may be associated with the severity of coronary atherosclerotic disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença da Artéria Coronariana
/
Sequência de Bases
/
Etnicidade
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Etnologia
/
Receptores OX40
/
Frequência do Gene
/
Genética
/
Genótipo
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS