Identification of a new human leukocyte antigen A allele, HLA-A*3020 / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To identify a novel human leukocyte antigen (HLA) A allele.</p><p><b>METHODS</b>A new HLA-A allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).</p><p><b>RESULTS</b>The novel HLA-A*30 allele was identical to A*300101 except that a nucleotide C at position 294 of exon 2 is substituted by A, resulting in codon 98 changed from GAC (D) to GAA (E).</p><p><b>CONCLUSION</b>A new HLA allele, HLA-A*3020, was identified, and was named officially by the WHO Nomenclature Committee.</p>