P53 abnormality and clinical prognosis of leukemia patients with complex chromosomal abnormalities / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the p53 deletion in leukemia patients with complex chromosomal abnormalities (CCA) and the clinical significance.</p><p><b>METHODS</b>The p53 deletion status of 38 leukemia cases with CCA and 24 cases without CCA were analyzed by interphase fluorescence in situ hybridization (I-FISH).</p><p><b>RESULTS</b>The frequency of p53 deletion in the 38 patients with CCA (44.74%) was significantly higher than that in the 24 cases without CCA (4.16%) (P<0.01). The rate of complete remission in 13 cases of acute leukemia with CCA was 15.4%, with median survival time (MST) of 105 days.</p><p><b>CONCLUSION</b>I-FISH is a rapid, accurate and sensitive technique for detection of p53 deletion, patients with CCA have a higher p53 deletion and a lower complete remission rate and MST.</p>