Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 29-33, 2010.
Article
em Zh
| WPRIM
| ID: wpr-349045
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the 1891-1892del TC polymorphism of regulator of G-protein signalling 2 (RGS2) gene with hypertension in Xinjiang Kazakh population.</p><p><b>METHODS</b>The case-control study was performed in 444 cases and 489 controls. The genotypes of the individuals in the 1891-1892del TC locus were identified by TaqMan method.</p><p><b>RESULTS</b>A significant association was observed between the1891-1892TC insertion/deletion polymorphism with hypertension in men (OR=1.698, P=0.03) and in the total population (OR=1.32, P=0.044). The mean systolic blood pressure and serum uric acid levels of the ID+DD carriers were significantly higher than that of the II carriers (adjusted, P=0.04 and P<0.01).</p><p><b>CONCLUSION</b>The results suggest that the D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene might be an independent risk factor for hypertension in Xinjiang Kazakhs; and the polymorphism may have some influence on serum uric acid level in this population.</p>
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Índice:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Ácido Úrico
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Sangue
/
Pressão Sanguínea
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Estudos de Casos e Controles
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China
/
Fatores de Risco
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Predisposição Genética para Doença
/
Proteínas RGS
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Povo Asiático
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2010
Tipo de documento:
Article