Trisomy 8 in chronic lymphocytic leukemia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 443-445, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-349057
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the incidence of trisomy 8 in chronic lymphocytic leukemia (CLL) and its significance in prognosis.</p><p><b>METHODS</b>A panel of probes and fluorescence in situ hybridization (FISH) were used to detect trisomy 8 in 151 CLL patients combined with chromosome karyotype analysis.</p><p><b>RESULTS</b>There were 2 patients (1.3%) with trisomy 8 in the 151 CLL patients, and the number of trisomy 8 cells was 8% and 10% respectively. The karyotypes were 47,XY,+8[2]/49,XY,+14,+20,+21[2]/ 46,XY[16], and 47,XX,+8[2]/46,XX[18], respectively.</p><p><b>CONCLUSION</b>Trisomy 8 was rare in CLL, and its significance in prognosis of CLL still remains unknown.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Trissomia
/
Cromossomos Humanos Par 8
/
Leucemia Linfocítica Crônica de Células B
/
Diagnóstico
/
Genética
/
Cariotipagem
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2009
Tipo de documento:
Artigo
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