A long-term observation and follow-up for patients with HBeAg/Anti-HBe seroconversion after lamivudine treatment / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 297-299, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-349131
ABSTRACT
<p><b>OBJECTIVE</b>To observe the resulting change in patients who achieved HBeAg/Anti-HBe seroconversion after lamivudine treatment.</p><p><b>METHODS</b>68 patients were observed for over 24 months. They were HBeAg/Anti-HBe with a seroconversion time > or = 6 months and the course of lamivudine treatment was > or = 18 months.</p><p><b>RESULTS</b>After lamivudine treatment, the rate of HBeAg/Anti-HBe seroconversion was 25.19%, the rate of YMDD mutations was 20.59%, and the rate of relapse was 27.94% for these patients that achieved HBeAg/Anti-HBe seroconversion in observation and in the follow-up period. Lamivudine was still an effective drug for these patients with relapses. The rate of relapse was in correlation to the patients' age and the ALT level before treatment. The rate of relapse was not correlated to the HBV DNA level before the course of treatment. YMDD mutations were not correlated to the relapses.</p><p><b>CONCLUSION</b>Even with a HBeAg/Anti-HBe seroconversion time > or = 6 months, the rate of relapse was still higher in patients with chronic hepatitis B that received lamivudine. The patients with long-term lamivudine treatment should be observed and have frequent follow-up visits.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Sangue
/
Seguimentos
/
Lamivudina
/
Hepatite B Crônica
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Anticorpos Anti-Hepatite B
/
Antígenos E da Hepatite B
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS