Enatiomeric separation of beta-blocking agents and analogs / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 414-418, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-349430
ABSTRACT
OBJECTIVE:
To evaluate enantiomeric separation methods for beta-blocking agents and analogs.METHODS:
Enantiomeric separation of racemates of 11 beta-blocking agents and their analogs was performed using chiral stationary phases and 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate (GITC).RESULTS:
These beta -blocker racemates were separated into enantiomers in one or several chormatographic states such as propranolol, bisoprolol, metoprolol, celiprolol, carvedilol, sotalol, propafenone, ephedrine, and zomitriptan. Temperature had a significant effect on the resolution of the drugs when using chiralcel OD. Lower temperatures were associated with higher resolutions.CONCLUSION:
When separating beta-blocking agents and their analogs, Chiralcel OD, Chiralpak AD, Chiral stationary phases and GITC chiral derivative reagents have complementary functions.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2002
Tipo de documento:
Artigo
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