Targeted therapy: resistance and re-sensitization / 癌症
Chinese Journal of Cancer
; (12): 496-501, 2015.
Article
em En
| WPRIM
| ID: wpr-349566
Biblioteca responsável:
WPRO
ABSTRACT
The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chemical compounds and recombinant antibodies have been developed to selectively target oncogenic signaling pathways in a broad array of tumor types. Although targeted therapeutic agents show impressive clinical efficacy and minimized adverse effects compared with traditional treatments, the challenging drug-resistant issue has also emerged to limit their benefits to cancer patients. In this regard, we aim to improve targeted therapy by presenting a systematic framework regarding the drug resistance mechanisms and alternative approaches to re-sensitize cancer cells/tissues therapeutically.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Transdução de Sinais
/
Resistencia a Medicamentos Antineoplásicos
/
Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Chinese Journal of Cancer
Ano de publicação:
2015
Tipo de documento:
Article