Epstein-Barr virus and the origin of Hodgkin lymphoma / 癌症
Chinese Journal of Cancer
;
(12): 591-597, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-349625
ABSTRACT
Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Virologia
/
Doença de Hodgkin
/
Células de Reed-Sternberg
/
Herpesvirus Humano 4
/
Infecções por Vírus Epstein-Barr
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2014
Tipo de documento:
Artigo
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