CAL-101,a novel agent of targeted therapy in hematological malignancies / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 530-533, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-349676
ABSTRACT
CAL-101 is a selective inhibitor of the phosphatidylinositol-3 kinase (PI3K), it inhibits the survival, proliferation and migration of tumor cells by directly inducing apoptosis and inhibiting micro-environmental interactions. It has been determined that the P110δ isoforms of PI3K expressed primarily in cells of hematopoietic lineage, such as B and T cells. This review focuses on the target, mechanism of action, the use and prospect of CAL-101 in tumors of blood and lymph systems.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Purinas
/
Transdução de Sinais
/
Neoplasias Hematológicas
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Quinazolinonas
/
Classe Ia de Fosfatidilinositol 3-Quinase
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2014
Tipo de documento:
Artigo
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