Dysregulation of E-cadherin in Chronic Rhinosinusitis with Nasal Polyps / 华中科技大学学报（医学）（英德文版）

ABSTRACT

E-cadherin is a key epithelial protein and adhesive molecule.This study detected the E-cadherin expression in patients with chronic rhinosinusitis with nasal polyps(CRSwNP)and controls,and analyzed its possible role in the pathogenesis of CRSwNP.The expression of E-cadherin was detected by using Western blotting and immunohistochemistry in controls and patients with CRSwNP.Computed tomography(CT)scan findings were scored.The results showed that the E-cadherin expression was up-regulated in patients with CRSwNP as compared with controls(P=0.039)and the positive staining was predominantly localized on the epithelial cell membrane.E-cadherin level was correlated negatively with Lund-Mackay scores in patients with CRSwNP(r=-0.604,P=-0.005).It is suggested that E-cadherin may be involved in the pathogenesis of CRSwNP and correlated with disease severity.