Establishment of animal model of breast cancer dormancy / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 760-763, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-350020
ABSTRACT
<p><b>OBJECTIVE</b>Tumor dormancy has been defined clinically as a condition in which tumor cells are present but do not grow for a long period of time. Breast cancer is noted for its long periods of tumor dormancy and metastases can occur many years after treatment.</p><p><b>METHOD</b>Simulating the characteristics of breast cancer patients after treatment, we established the animal model of breast cancer dormancy by inoculating 500 Ca761-03 cells into the limb muscle of 615 mice and then selecting animals with tumor dormancy 2 months post inoculation (corresponding to 5 years for humans).</p><p><b>RESULTS</b>Two months after inoculation of Ca761-03 cells into the muscle of 615 mice, tumor occurred in 30% of the mice. The remaining 70% of mice did not show tumor growth. After repeated traumatic stimulation, 90% of the mice developed tumors after 5 months, therefore representing tumor dormancy.</p><p><b>CONCLUSIONS</b>These results demonstrate that breast cancer cells can remain in a dormant state for long periods of time in vivo. Trauma can stimulate the dormant tumor cells to proliferate again, and causes tumor relapse. This murine model system promises a sound animal model for the study of solid tumor dormancy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias da Mama
/
Distribuição Aleatória
/
Sobrevivência Celular
/
Neoplasias do Colo do Útero
/
Progressão da Doença
/
Linhagem Celular Tumoral
/
Modelos Animais de Doenças
/
Recidiva Local de Neoplasia
/
Transplante de Neoplasias
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2007
Tipo de documento:
Artigo
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