Expression of Fas, FasL, and NF-kappa B in the process of osteoclast-like cell apoptosis effected by sodium fluoride / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 491-494, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-350078
ABSTRACT
<p><b>OBJECTIVE</b>To detect the changes in the expression of apoptosis signals Fas, FasL and NF-kappa B in the process of osteoclast-like cell (OLC) apoptosis effected by sodium fluoride.</p><p><b>METHODS</b>After co-culture of osteoclast-like cells with 0, 5, 10 and 15 mg/L sodium fluoride, Fas, FasL and NF-kappa B antibody expressions were detected by immune-histochemistry.</p><p><b>RESULTS</b>The expression of Fas and FasL increased with the concentration of the sodium fluoride, however the expression of NF-kappa B decreased with the concentration of sodium fluoride.</p><p><b>CONCLUSION</b>In the process of OLC apoptosis induced by sodium fluoride, the expression of Fas and FasL increased, and that of NF-kappa B decreased with the concentration of sodium fluoride respectively, and the changes of the expression present a dose-dependent pattern.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoclastos
/
Farmacologia
/
Glicoproteínas de Membrana
/
NF-kappa B
/
Apoptose
/
Receptor fas
/
Biologia Celular
/
Proteína Ligante Fas
/
Fluoretos
/
Ligantes
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2002
Tipo de documento:
Artigo
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