Study of the gene expression pattern in the Kkay mouse with type 2 diabetes by genomic-scale gene expression analysis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 462-465, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-350084
ABSTRACT
<p><b>OBJECTIVE</b>To study the genes differentially expressed in the liver of Kkay diabetic and normal mice by genomic-scale gene expression analysis.</p><p><b>METHODS</b>cDNA microarray chips containing 8,192 cDNAs were used to explore the gene expression pattern of Kkay mouse liver.</p><p><b>RESULTS</b>One hundred and fifty-four genes were screened out, including 68 complete cDNAs and expressed sequence tags, and among them 40 genes were up-regulated and 114 genes were down-regulated respectively.</p><p><b>CONCLUSION</b>Most of the gene expression analysis results were consistent with previous study, and the gene expression pattern of Kkay mouse based on cDNA microarray could be used for high-throughout screening out the genes associated with type 2 diabetes.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA Mensageiro
/
Expressão Gênica
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Perfilação da Expressão Gênica
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 2
/
Genética
/
Fígado
/
Metabolismo
/
Camundongos Mutantes
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2002
Tipo de documento:
Artigo
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