Effect of vitamin E on memory and brain monoaminergic neurotransmitter in chronic episodic hypoxia rat / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 333-336, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-350097
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Vitamin E (VitE) on memory and brain monoaminergic neurotransmitter level in chronic episodic hypoxia (EHYP) rat.</p><p><b>METHODS</b>VitE [50 IU/ (250 g.d) or 5 IU/ (250 g.d)] was given to the EHYP rat model. The memory was evaluated by the passive avoidance test and the levels of monoaminergic neurotransmitter, including norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT), were determined in three different brain regions (including cerebral cortex, hippocampus and striatum) using high performance liquid chromatography and electrochemical detection (HPLC-ECD).</p><p><b>RESULTS</b>The performance on passive avoidance test of EHYP rats was worse than that of controlled rats (P < 0.01). The performance of rats in two different treatment groups was better than that of EHYP rats (P < 0.05), the performance of rats in high-dose group was worse than that of rats in low-dose group (P < 0.05). Compared with controlled rats, levels of monoaminergic neurotransmitters in different brain regions of EHYP rats decreased significantly (P < 0.05). Compared with EHYP rats, level of NE and DA in cerebral cortex and level of monoamine (NE, DA, and 5-HT) in hippocampus and striatum of low-dose treated rats were increased significantly (P < 0.05). Different with low-dose treated rats, only level of monoamine (NE, DA, and 5-HT) in striatum and level of 5-HT in hippocampus in high-dose treated rats were increased significantly (P < 0.05), as compared with the EHYP rats.</p><p><b>CONCLUSIONS</b>vitE can improve memory and increase brain monoaminergic neurotransmitter of EHYP rats. Moreover, the effect of low-dose vitE is better than that of high-dose VitE.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Aprendizagem da Esquiva
/
Vitamina E
/
Encéfalo
/
Monoaminas Biogênicas
/
Dopamina
/
Serotonina
/
Norepinefrina
/
Ataque Isquêmico Transitório
/
Ratos Sprague-Dawley
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2003
Tipo de documento:
Artigo
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