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The effect of experimental osteoporosis on bone healing of autologous iliac crest graft around implants / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 435-438, 2010.
Artigo em Chinês | WPRIM | ID: wpr-350318
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influences of experimental osteoporosis (OP) on bone healing of autologous iliac crest graft around dental implants in rabbits.</p><p><b>METHODS</b>Twenty Japanese rabbits were randomly divided into two groups. Bilaterally ovariectomy was performed on experimental group and control group received sham-operation. Twelve weeks later, femoral bones were examined for bone mineral density (BMD) to verify OP status. Then bone defects were made in the proximal metaphysis of the tibiae and autologous iliac crest grafts with simultaneous implant placement were performed. The animals were killed at 8 and 12 weeks after bone graft surgery. Undecalcified sections were prepared and examined histologically and histomorphometrically.</p><p><b>RESULTS</b>Osteoporotic status caused by ovariectomy was verified by significantly decreased BMD in experimental group (P < 0.001). At 8 and 12 weeks after bone graft surgery, osseointegration was observed in both groups. However, thickness of cortical bone (TCB), bone volume in cancellous area (BVC), implant-bone contact rate (IBCR) at bone graft area all significantly decreased in experimental group when compared with control group (P < 0.01). Newly formed bone was also less in experimental group than that in control group.</p><p><b>CONCLUSION</b>Although experimental OP may not delay osseointegration of dental implants in autologous iliac crest graft, it certainly promotes resorption of bone grafts, decreases cancellous bone volume and implant-bone contact rate. Therefore it may be an important risk factor for patients receiving autologous bone graft with simultaneous implant placement.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteoporose / Patologia / Transplante / Ovariectomia / Implantes Dentários / Osseointegração / Transplante Ósseo / Ílio Tipo de estudo: Fatores de risco Limite: Animais Idioma: Chinês Revista: West China Journal of Stomatology Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteoporose / Patologia / Transplante / Ovariectomia / Implantes Dentários / Osseointegração / Transplante Ósseo / Ílio Tipo de estudo: Fatores de risco Limite: Animais Idioma: Chinês Revista: West China Journal of Stomatology Ano de publicação: 2010 Tipo de documento: Artigo