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Insulin neuroprotection and the mechanisms / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 976-981, 2015.
Artigo em Inglês | WPRIM | ID: wpr-350369
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action.</p><p><b>DATA SOURCES</b>The study is based on the data from PubMed.</p><p><b>STUDY SELECTION</b>Articles were selected with the search terms "insulin", "blood glucose", "neuroprotection", "brain", "glycogen", "cerebral ischemia", "neuronal necrosis", "glutamate", "γ-aminobutyric acid".</p><p><b>RESULTS</b>Insulin has neuroprotection. The mechanisms include the regulation of neurotransmitter, promoting glycogen synthesis, and inhibition of neuronal necrosis and apoptosis. Insulin could play its role in neuroprotection by avoiding hypoglycemia and hyperglycemia.</p><p><b>CONCLUSIONS</b>Intermittent and long-term infusion insulin may be a benefit for patients with ischemic brain damage at blood glucose 6-9 mmol/L.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Glicemia / Isquemia Encefálica / Fármacos Neuroprotetores / Usos Terapêuticos / Hiperglicemia / Insulina Limite: Humanos Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Glicemia / Isquemia Encefálica / Fármacos Neuroprotetores / Usos Terapêuticos / Hiperglicemia / Insulina Limite: Humanos Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2015 Tipo de documento: Artigo