Insulin neuroprotection and the mechanisms / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 976-981, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-350369
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action.</p><p><b>DATA SOURCES</b>The study is based on the data from PubMed.</p><p><b>STUDY SELECTION</b>Articles were selected with the search terms "insulin", "blood glucose", "neuroprotection", "brain", "glycogen", "cerebral ischemia", "neuronal necrosis", "glutamate", "γ-aminobutyric acid".</p><p><b>RESULTS</b>Insulin has neuroprotection. The mechanisms include the regulation of neurotransmitter, promoting glycogen synthesis, and inhibition of neuronal necrosis and apoptosis. Insulin could play its role in neuroprotection by avoiding hypoglycemia and hyperglycemia.</p><p><b>CONCLUSIONS</b>Intermittent and long-term infusion insulin may be a benefit for patients with ischemic brain damage at blood glucose 6-9 mmol/L.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glicemia
/
Isquemia Encefálica
/
Fármacos Neuroprotetores
/
Usos Terapêuticos
/
Hiperglicemia
/
Insulina
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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