Antagonistic effect of curcumin on lipid peroxidation of rats poisoned by paraquat / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 609-611, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-350527
ABSTRACT
<p><b>OBJECTIVE</b>To explore the pathogenesis of paraquat poisoning and observe the change in lipid peroxidation of rats treated with different doses of curcumin.</p><p><b>METHODS</b>A total of 50 8-week-old male Wistar rats (clean grade) were randomly divided into high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin treatment group, poisoned group, and blank control group. Glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) levels in rat serum were measured at 1, 3, 7, 14, and 21 d post paraquat injection.</p><p><b>RESULTS</b>Compared with the blank control group, other groups had significantly higher MDA levels but lower SOD, GSH-PX, and CAT activities. The high-dose, low-dose curcumin plus conventional treatment, and high-dose curcumin treatment groups had significantly lower serum lipid peroxidation levels compared with the poisoned group and among them the high-dose curcumin plus conventional treatment group had the most significant improvement.</p><p><b>CONCLUSION</b>Curcumin can significantly decrease serum lipid peroxidation level in rats and inhibit and delay the occurrence and progression of the damage to the body.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Paraquat
/
Farmacologia
/
Superóxido Dismutase
/
Sangue
/
Peroxidação de Lipídeos
/
Catalase
/
Distribuição Aleatória
/
Ratos Wistar
/
Curcumina
/
Toxicidade
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2015
Tipo de documento:
Artigo
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