Comparative analysis of serum proteomic profiles between patients with silicosis and chronic bronchitis / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 589-591, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-350532
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the differences in serum proteomic profiles between patients with silicosis and chronic bronchitis and to investigate the pathogenesis, clinical diagnosis, and treatment of these two disease.</p><p><b>METHODS</b>Serum samples from patients with stage I silicosis and chronic bronchitis were collected. Two-dimensional gel electrophoresis was performed and protein plots with expression differences higher than 2-fold were identified and further analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.</p><p><b>RESULTS</b>Compared with the silicosis group, the chronic bronchitis group had 11 up-regulated proteins and 23 down-regulated proteins. The chronic bronchitis group had high expression of proteins such as interferon beta precursor, apolipoprotein precursor, and transforming growth factor beta1 precursor. The silicosis group had high expression of proteins such as interleukin-6, granzyme A, cathepsin G, and glycoprotein precursor.</p><p><b>CONCLUSION</b>The differentially expressed proteins are mainly involved in the activity of serine enzymes, cytotoxicity, inflammation response, and apolipoprotein transfer and play different roles in silicosis and chronic bronchitis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Silicose
/
Espectrometria de Massas
/
Glicoproteínas
/
Eletroforese em Gel Bidimensional
/
Regulação para Baixo
/
Regulação para Cima
/
Química
/
Interleucina-6
/
Bronquite Crônica
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2015
Tipo de documento:
Artigo
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