Low-dose daily de-escalatory administration of tadalafil for psychological erectile dysfunction / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect of low-dose daily de-escalatory administration of tadalafil on psychological erectile dysfunction (ED).</p><p><b>METHODS</b>We randomized 84 psychological ED patients into an observation and a control group of equal number to receive low-dose daily de-escalatory administration and on-demand medication of tadalafil, respectively, both for 2 months. We compared the scores on IIEF-5 and erection hardness (EHS) between the two groups before and after the treatment.</p><p><b>RESULTS</b>The treatment and follow-up were accomplished for 79 cases, with 5 withdrawals in the control group. The IIEF-5 and EHS scores were remarkably improved in both the observation and control groups after treatment. The rate of therapeutic effectiveness was significantly higher in the observation group than in the control (95.2% vs 86.5%, P < 0.05).</p><p><b>CONCLUSION</b>Low-dose daily de-escalatory administration of tadalafil is highly effective and even better than on-demand medication of tadalafil for psychological ED.</p>