Expression of Eag1 K(+) channel in prostate cancer and its significance / 中华男科学杂志
National Journal of Andrology
; (12): 205-209, 2013.
Article
em Zh
| WPRIM
| ID: wpr-350910
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of the Eag1 K( +) channel in the prostate cancer (PCa) tissue, its correlation with the development and progression of PCa, and whether it could be a target for the diagnosis and treatment of PCa.</p><p><b>METHODS</b>We used RT-PCR and immunohistochemistry to determine the mRNA and protein expressions of the Eag1 K(+) channel in the normal peritumoral tissue of androgen-dependent PCa (ADPCa) (group A) and androgen-independent PCa (AIPCa) (group B) as well as in the tumorous tissue of ADPCa (group C) and AIPCa (group D).</p><p><b>RESULTS</b>The relative coefficients of the mRNA expression of the Eag1 K(+) channel were 0.265 +/- 0.413, 0.167 +/- 0.511, 2.673 +/- 2.988 and 2.815 +/- 2.901 in groups A, B, C and D, respectively, increased significantly in the latter two groups (P < 0.05). The positive rates of the protein expression of the Eag1 K (+) channel were significantly higher in groups C (88.9%) and D (86.7%) than in A (7.4%) and B (6.7%) (P < 0.05).</p><p><b>CONCLUSION</b>The Eag1 K(+) channel might be involved in the pathophysiological processes of PCa, and is expected to be a valuable target for the diagnosis and treatment of PCa.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Próstata
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Neoplasias da Próstata
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RNA Mensageiro
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Imuno-Histoquímica
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Reação em Cadeia da Polimerase Via Transcriptase Reversa
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Canais de Potássio Éter-A-Go-Go
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Genética
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Metabolismo
Limite:
Humans
/
Male
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2013
Tipo de documento:
Article