Experimental study on effects of Shenshuai compound medicine on acute renal failure rats and secretion cell factors / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 425-428, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-350921
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of the experiential compound prescription Shenshuai compound medicine (SSCM) on acute renal failure (ARF) rats, and expose its mechanism.</p><p><b>METHOD</b>Male SD rats were allocated into four groups at random. Except normal group, the others were injected glycerin into the musculi to induce a model of ARF. At the same time, rats in normal and model groups were given a dose (10 mL x kg(-1)) of normal saline; rats in the other two groups were given verapamil (Vp) 40 mg x kg(-1) x d(-1) and SSCM 22.5 mg x kg(-1) x d(-1) respectively by gastric gavages. In this way they were killed at 24 h after injecting glycerin.</p><p><b>RESULT</b>In contrast with model group, SSCM and Vp could ameliorate the renal function of acute tubular necrosis (ATN) rats markedly, in a way protect the renal inherent cell ultrastructure such as tubular epithelial cell etc at ATN early-stage; especially SSCM could enhance NO contents in serum, and was reduce ET levels inplasma, evidently cut down TNF-alpha contents in serum, and was partly superior to Vp.</p><p><b>CONCLUSION</b>It is indicated that SSCM can adjust thebalance of contract and stretch blood vessal active substance and clear away initiate inflammatory medium, consequently alleviate renal pathological changes, prevent and treat ARF.</p>
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Plantas Medicinais
/
Sangue
/
Medicamentos de Ervas Chinesas
/
Distribuição Aleatória
/
Química
/
Endotelinas
/
Fator de Necrose Tumoral alfa
/
Ratos Sprague-Dawley
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2006
Tipo de documento:
Artigo
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