Effects and mechanism of total saponins of Psammosilene tunicoids against rheumatoid arthritis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 419-421, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-350923
ABSTRACT
<p><b>OBJECTIVE</b>To observe the antiarthritic effects and the possible mechanism of total saponins of Psammruosilene tunicoids (TSPT) against rheumatoid arthritis (RA).</p><p><b>METHOD</b>After establishing AA rat model, the TSPT'S antiarthritic effects and mechanism against RA were studied through observing the changes of ankle swelling, arthritis index and levels of IL-1beta and TNF-alpha after medication.</p><p><b>RESULT</b>TSPT could effectively inhibits articular swelling, decrease arthritis index and regulate down the content of IL-1beta and TNF-alpha in the inflammatory tissue soak of AA rats.</p><p><b>CONCLUSION</b>TSPT has good antiarthritic effects and the possible mechanism may be related to its down-regulation of IL-1beta and TNF-alpha.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Plantas Medicinais
/
Artrite Reumatoide
/
Saponinas
/
Química
/
Interleucina-1
/
Fator de Necrose Tumoral alfa
/
Ratos Wistar
/
Raízes de Plantas
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2006
Tipo de documento:
Artigo
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