Effects of total base of Sophora alopecuroides on expression of SOD, MDA, NO, MPO in rats with experimental colitis / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of total base of Sophora alopecuroides on expression of SOD, MDA, NO, MPO in rats with experimental colitis (UC).</p><p><b>METHOD</b>SD rats were randomized into 6 groups and colitis was induced by administrating 2,4,6-trinitrobenzesulphonic acid (TNB) recatlly in rats. Rats were given drug by stomach after the first day for 3 weeks, and sacrificed at 23rd day to determine the content of MDA and activities of SOD, NO, MPO in colonic mucosa, and to estimate the symptom and colonic histology.</p><p><b>RESULT</b>In UC rats, SOD was significantly decreased whereas MDA, NO, MPO were increased when compared with the normal group (P < 0.05). In all treatment groups, Sophora alopecuroides could increase SOD, decrease MDA, NO, MPO (P < 0.05), and improve the symptoms and histological damages.</p><p><b>CONCLUSION</b>The total dose of S. alopecuroides may ameliorates or alleviate the symptoms of UC through inhibiting oxygen free radical reaction, decreasing the generation of NO and exerting anti-inflammatory effects.</p>