Effect of mica granule on the expression of gene-protein associated with cancer in gastric mucosa tissue of chronic atrophic gastritis rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 312-316, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-350950
ABSTRACT
<p><b>OBJECTIVE</b>To research the regulative effect of mica monomer granule preparation on the expression of gene associated with cancer in gastric mucosa tissue of experimental chronic atrophic gastritis (CAG) rats.</p><p><b>METHOD</b>To treat experimental CAG rats using mica monomer granule preparation with three different dosage-high, moderate and low level respectively. To observe the expression changes of mutant antioncogene-p53 gene-protein, oncogene p21, antioncogene p16 and anti-apoptosis gene bcl-2 in gastric mucosa of CAG rats by two-step ways of EnVision system in immunohistochemical method.</p><p><b>RESULT</b>There was the tendency that mica monomer granule preparation with three different dosage could decrease the expression of p53 as well as p21, and mica had the obvious regulative effects on deletion of p16 and high-expression of bcl-2. It could also alleviate the inflammation of gastric mucosa and promote the regeneration of gland.</p><p><b>CONCLUSION</b>The treatment and reversion action of mica on chronic atrophic gastritis is probably related with the regulative effect on the expression of gene associated with cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Materia Medica
/
Distribuição Aleatória
/
Proteína Oncogênica p21(ras)
/
Proteína Supressora de Tumor p53
/
Ratos Sprague-Dawley
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Inibidor p16 de Quinase Dependente de Ciclina
/
Proteínas Supressoras de Tumor
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2006
Tipo de documento:
Artigo
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