Impact on the model of rat osteoarthritis of jingu tablet / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the influence of Jingu tablet (JGT) on the development and repair of osteoarthritis (OA).</p><p><b>METHOD</b>The admixture of 4% papain and 0.3 mol x L(-1) cysteine was injected into the rat's knee joint to make the model of rat OA, and distilled water, Gucining Capsule and JGT was given ig simultaneously to treat for 4 weeks in succession, and then animals were killed to measure every index.</p><p><b>RESULT</b>JGT could obviously improve the scope of activities of knee joint. There were significant differences between every dosage group and model group. In every dosage group, JGT could suppress the swelling of thickness of slippery membrane of joint, alleviate the inflammation symptoms of OA and obviouslical improve the pathologicol changes of slippery membrane and cartilage. JGT could also obviously reduce the content of MDA of slippery membrane and lighten the degree of cell damage.</p><p><b>CONCLUSION</b>JGT can lighten the retrograde affection of joint cartilage, obviously suppress the slippery membrane's inflammation and alleviate the scathing degree of cell. Therefore JGT has definite remedial effect to OA.</p>