Preparation of Xionggui nasal sprays and its evaluation in release in vitro and absorption in vivo / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study Xionggui nasal sprays and its evaluation in release in vitro and absorption in vivo.</p><p><b>METHOD</b>Establishing the best prescription of Xionggui nasal sprays through orthogonal design methods, The in vitro release action of Xionggui nasal sprays was studied using dynamic dialyse method. The in vivo rat nasal recirculation methods were used to study the rule of Xionggui nasal sprays absorption.</p><p><b>RESULT</b>The optimum prescription was: Pemulen TR-1 0.35%, EDTA 0.2%, PEG400 1%, xanthan gum 0.2%; trolamine: right amount(adjust pH). Its release in vitro and absorption in vivo meet to Higuchi distribution.</p><p><b>CONCLUSION</b>The preparation method of Xionggui nasal sprays was appropriate. The release of drug and its uptake was well correlated.</p>