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Are cancer stem cells the sole source of tumor? / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 621-625, 2014.
Artigo em Inglês | WPRIM | ID: wpr-351028
ABSTRACT
Tumors are believed to consist of a heterogeneous population of tumor cells originating from rare cancer stem cells (CSCs). However, emerging evidence suggests that tumor may also originate from non-CSCs. To support this viewpoint, we are here to present definitive evidence indicating that the number of tumorigenic tumor cells is greater than that of CSCs in tumor, and tumor can also derive from non-CSCs. To achieve this, an idealized mathematical model was employed in the present study and theoretical calculation revealed that non-CSCs could initiate the occurrence of tumor if their proliferation potential was adequate. Further, experimental studies demonstrated that 17.7%, 38.6% and 5.2% of tumor cells in murine B16 solid melanoma, H22 hepatoma and Lewis lung carcinoma, respectively, were potentially tumorigenic. Thus, based on the aforementioned findings, we propose that the scarce CSCs, if exist, are not the sole source of a tumor.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fatores de Tempo / Células-Tronco Neoplásicas / Algoritmos / Melanoma Experimental / Ensaio Tumoral de Célula-Tronco / Diferenciação Celular / Carcinoma Pulmonar de Lewis / Linhagem Celular Tumoral / Proliferação de Células Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fatores de Tempo / Células-Tronco Neoplásicas / Algoritmos / Melanoma Experimental / Ensaio Tumoral de Célula-Tronco / Diferenciação Celular / Carcinoma Pulmonar de Lewis / Linhagem Celular Tumoral / Proliferação de Células Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2014 Tipo de documento: Artigo