Effects of Tongxinluo on neuron ultrastructure and endothelial cell self-repairing ability in hypoxia preconditioning mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 396-399, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-351146
ABSTRACT
<p><b>OBJECTIVE</b>To observe the ultrastructure changes of cerebral cortex neuron and endothelial cell in hypoxia preconditioning mice and the effects of Tongxinluo (TXL, Chinese traditional medilihe) on them.</p><p><b>METHODS</b>Mice were randomly divided into 4 groups control group, hypoxia group, hypoxia preconditioning (HP) group and Tongxinluo (TXL) group. The hypoxia preconditioning mice were exposed by repetitive hypoxia for 5 runs. The animal's tolerance time of each hypoxia run was recorded. The ultrastructure change of cerebral neuron and endothelial cell were studied by electron microscope.</p><p><b>RESULTS</b>The hypoxic tolerance time in HP and TXL groups were significantly increased run by run. Compared with HP group, the tolerance time of TXL group were increased in every run. The ultrastructure of cerebral neuron and endothelial cell in hypoxia group changed obviously, mitochondrion and endoplasmic reticulum destroyed. However they were slighter in HP group than those in hypoxia group. The change in TXL group had no obvious differentce with control group and were slighter than those in HP group.</p><p><b>CONCLUSION</b>Hypoxia preconditioning shows that organism has a strong self-repairing ability. Tongxinluo self-repairing; could increase self-repairing ability and adaptive ability of mice to hypoxia obviously.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Adaptação Fisiológica
/
Hipóxia Encefálica
/
Córtex Cerebral
/
Precondicionamento Isquêmico
/
Células Endoteliais
/
Hipóxia
/
Métodos
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2011
Tipo de documento:
Artigo
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