Influence of acute hypoxia on CHL1 expression in different tissues of mice / 中国应用生理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effects of acute hypoxia on the cell adhesion molecule close homologue of L1 (CHL1) expression in different brain areas and main organs (heart, lung, kidney) of mice, and provide a basis for the role of CHL1 in hypoxia injury.</p><p><b>METHODS</b>Mice were randomly divided into two groups (n=10) normoxia group and hypoxia group. Hypoxia group were treated by acute hypoxia (8% O2, 8 h). Protein expression changes in different tissues were evaluated by Western blot.</p><p><b>RESULTS</b>In central nervous system, CHL1 protein expressions were down-regulated in cerebral cortex, hypothalamus and brain stem by acute hypoxia and up-regulated in cerebellum. In heart and lung, CHL1 protein expression were down-regulated by acute hypoxia.</p><p><b>CONCLUSION</b>CHL1 protein expressions were changed in different tissues after acute hypoxia, which suggested CHL1 might play an important role in hypoxia damage regulation.</p>