Study on hypoglycemic potential of Radix Rhemanniae and Rhizoma Anemanhenae

ABSTRACT

The hypoglycemic effect of TD-1 - a mixture of EtOH extract from the roots of Rehmannia glutinosa (Scrophulariaceae) and Anemarrhena asphodeloides (Liliaceae) - was investigated in normal Swiss mice. TD-1 (80mg/kg - 160 mg/kg) showed no clear hypoglycemic effect after single oral administration (8 hours, p>0.05). TD-1 (80 mg/kg) reduced the blood glucose of the mice from 142.0 (6.8 mg/dl to 61.2 (3.7 mg/dl 7 hours after single peritoneum injection (p<0.01). The results confirm the roles of mentioned above plants as traditional medicinal plants in diabetic treatment.