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Methods for establishing animal model of bronchopulmonary dysplasia and their evaluation / 中国当代儿科杂志
Article em Zh | WPRIM | ID: wpr-351390
Biblioteca responsável: WPRO
ABSTRACT
With the development of treatment, the survival rate of premature infants has significantly increased, especially extremely premature infants and very low birth weight infants. This has led to an increase in incidence of bronchopulmonary dysplasia (BPD) year by year. BPD has been one of the most common respiratory system diseases in premature infants, especially the small premature infants. Arrested alveolar development is an important cause of BPD. Therefore, the mechanism of arrested alveolar development and the intervention measures for promoting alveolar development are the focuses of research on BPD. Selecting the appropriate animal model of BPD is the key to obtaining meaningful results in the basic research on BPD. Based on above, several common methods for establishing an animal model of BPD and the corresponding changes in pathophysiology are summarized and evaluated in order to provide a reference for selecting the appropriate animal model in studies on the pathogenesis, pathophysiology, and prevention and control strategies of BPD.
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Respiração Artificial / Displasia Broncopulmonar / Hiperóxia / Modelos Animais de Doenças Limite: Animals / Humans Idioma: Zh Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2017 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Respiração Artificial / Displasia Broncopulmonar / Hiperóxia / Modelos Animais de Doenças Limite: Animals / Humans Idioma: Zh Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2017 Tipo de documento: Article