Association between risk factors during maternal pregnancy and the neonatal period and childhood bronchial asthma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 49-53, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-351403
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of the risk factors during maternal pregnancy and the neonatal period with childhood bronchial asthma.</p><p><b>METHODS</b>A total of 306 children with asthma (asthma group) and 250 healthy children (control group) were enrolled. Their clinical data during the neonatal period and the maternal data during pregnancy were retrospectively studied.</p><p><b>RESULTS</b>The univariate analysis showed that there were significant differences in the rates of maternal use of antibiotics during pregnancy, use of antibiotics and probiotics during the neonatal period, preterm birth, cesarean section, low birth weight, and breast feeding (>6 months) between the asthma and control groups (P<0.05). The multivariate logistic regression analysis showed that use of antibiotics during pregnancy (OR=3.908, 95%CI 1.277-11.962), use of antibiotics during neonatal period (OR=24.154, 95%CI 7.864-74.183), preterm birth (OR=8.535, 95%CI 2.733-26.652), and cesarean section (OR=4.588, 95%CI 2.887-7.291) were independent risk factors for childhood asthma. The use of probiotics during the neonatal period (OR=0.014, 95%CI 0.004-0.046) and breast feeding (>6 months) (OR=0.161, 95%CI 0.103-0.253) were protective factors for childhood asthma.</p><p><b>CONCLUSIONS</b>The early prevention of childhood asthma can be improved by reducing the use of antibiotics during pregnancy, reducing cesarean section, avoiding abuse of antibiotics during the neonatal period, trying breast feeding and taking probiotics in early stage.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Aleitamento Materno
/
Modelos Logísticos
/
Estudos Retrospectivos
/
Fatores de Risco
/
Probióticos
/
Usos Terapêuticos
/
Antibacterianos
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Recém-Nascido
/
Gravidez
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS