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Case-control study on the effect of ulinastatin on postoperative complications in elderly patients undergoing hip joint replacement / 中国骨伤
China Journal of Orthopaedics and Traumatology ; (12): 459-462, 2011.
Artigo em Chinês | WPRIM | ID: wpr-351706
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the preventive effects of ulinastatin (Uti) on postoperative complications in elderly patients undergoing hip joint replacement.</p><p><b>METHODS</b>From Angust 2009 to June 2010, 160 elderly patients undergoing selective hip joint replacement with ASA I to II were assessed according to American Society of Anesthesiologists classification, including 81 males and 79 females ranging in age from 65 to 83 years (mean 73.9 years). All the patients were divided into 2 groups according to random number table (80 patients in each group) control group (group C) and ulinastatin group (group U). The patients in Group U received intravenous injection of ulinastatin with a dose of 10,000 U/kg before skin incision,and then with dose of 5000 U/kg respectively at 1, 2 and 3 days after operatio. The patients in Group C received the same volume of normal saline instead of ulinastatin. Blood samples were taken preoperatively,at the end of surgery and 1, 2, 3 days after operation for determination of ALT, AST, Scr, BUN and Plasma D-dimer. Deep vein thrombosis and postoperative cognitive dysfunction (POCD) were also examined through color Doppler ultrasonography and neuroeognirive assessment on the postoperative 3 days respectively.</p><p><b>RESULTS</b>Compared with the preoperative values, the contents of ALT, AST, Scr, BUN and plasma D-dimer in each group all increased. Compared with group C,the values of ALT, AST, Scr, BUN and plasma D-dimer decreased markedly (P < 0.05). The incidence rate of DVT and POCD was 0 and 3.75% in group U, which were lower than those of patients in the group C (40%, 27.5%) respectively.</p><p><b>CONCLUSION</b>Intravenous infusion of ulinastatin during operation can protect important organ function, correct blood hypercoagulability, lower the occurrence of DVT and POCD, and prevent the postoperative complications in some degree.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Complicações Pós-Operatórias / Nitrogênio da Ureia Sanguínea / Produtos de Degradação da Fibrina e do Fibrinogênio / Glicoproteínas / Estudos de Casos e Controles / Inibidores da Tripsina / Transtornos Cognitivos / Artroplastia de Quadril / Trombose Venosa / Usos Terapêuticos Tipo de estudo: Estudo observacional / Fatores de risco Limite: Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: China Journal of Orthopaedics and Traumatology Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Complicações Pós-Operatórias / Nitrogênio da Ureia Sanguínea / Produtos de Degradação da Fibrina e do Fibrinogênio / Glicoproteínas / Estudos de Casos e Controles / Inibidores da Tripsina / Transtornos Cognitivos / Artroplastia de Quadril / Trombose Venosa / Usos Terapêuticos Tipo de estudo: Estudo observacional / Fatores de risco Limite: Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: China Journal of Orthopaedics and Traumatology Ano de publicação: 2011 Tipo de documento: Artigo